Diuretics such as loops and thiazides decrease the filtration fraction.
2.
This would be reflected by a high filtration fraction, showing that the kidneys have to do more work with the fluid they are receiving.
3.
Catecholamines ( Norepinephrine and Epinephrine ) increase the filtration fraction by vasoconstriction of afferent and efferent arterioles, which is possibly activated by alpha 1 adrenergic receptors.
4.
The device s design requirements would require the filtration fraction in the glomerulus to vary between 15 %-20 %, or the filtration reabsorption in the proximal convoluted tubule to vary between 65 %-70 %, and finally the urea concentration in urine ( collected at one of the two outlets of the device ) to vary between 200-400mM.
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